RIZZOLI & ISLES follows Boston detective Jane Rizzoli (Harmon) and medical examiner Maura Isles (Sasha Alexander), complete opposites and good friends who solve crimes and bust some of Boston's most notorious criminals. Growing up at opposite ends of the economic spectrum, the two remain strikingly different from one another in many ways. Jane, the only female detective in Boston's homicide division, is a tough and gutsy cop who doesn't let her guard down (except with Maura), dodges her overprotective mother and is better at basketball than her brother. Maura, meanwhile, is usually more comfortable among the dead than the living. She is always impeccably dressed in designer duds with a steady, sometimes icy temperament. And she is working on curbing her tendency to diagnose the people she meets - including her first dates. Jane and Maura often find themselves working together as both use their brilliant minds and expertise to figure out the "who done it" as well as the "how done it" of Boston's most complex cases.